
I caused my son to get EXTREMELY hyperactive. Like so many mothers of ASD kids, I was desperate and tried DMG back about 10 years ago. This product is then converted to DMG HCL by adding hydrochloric acid. The synthesis of this form of DMG involves the alkylation of glycine by using formic acid and formaldehyde. Health supplements often contain DMG in the form of its hydrochloride salt, commonly known as DMG HCL. As a supplement, it is purported to offer a number of health benefits, from enhancing physical performance to. Could you please advice on which one I should start on first? And what is the difference of effects between DMG and TMG? Dimethylglycine, also known as DMG, is a natural substance found in both plant and animal cells, and is derived from the amino acid glycine (see reference 1 under Clinical Summary para 1). However I still am not sure if i should take dimethylglycine (DMG) or trimethylglycine (TMG). Some studies suggest that TMG could decrease homocysteine levels, boost athletic performance, improve insulin resistance, and enhance the effectiveness of certain antidepressants.Hi I am a 22 yr old athlete and I am considering the use of methyl supplements for endurace, muscle growth and growth.

That’s because these conditions may be linked with elevated homocysteine levels that TMG could help lower ( 20, 21, 22). What’s more, this supplement may also improve symptoms of depression and anxiety. Interestingly, in a small study including 64 people with depression, those who took both SAMe and TMG for 12 months experienced greater improvement in their symptoms than those who took SAMe alone ( 19). In particular, TMG has been shown to increase the effects of S-adenosyl-methionine (SAMe), a type of medication used to treat mild to moderate depression ( 17, 18). Some research shows that TMG supplements could improve how well certain types of antidepressant medications work. Still, more research is needed to better understand how TMG may affect insulin resistance in humans. This is when insulin isn’t effective at suppressing sugar production in the liver ( 16). What’s more, one mouse study from 2010 found that TMG supplements could reverse insulin resistance in the liver. Plus, in an animal study, administering TMG supplements to mice on a high fat diet improved fat metabolism and decreased insulin resistance ( 15). Several studies have found that TMG supplements could improve insulin resistance, a condition that impairs your body’s ability to use the hormone insulin to regulate blood sugar levels ( 13).įor example, a study in nearly 2,400 people associated a higher intake of choline and betaine with decreased insulin resistance ( 14). That’s why more studies are needed before experts can confidently recommend TMG as an athleticism-boosting supplement ( 10, 11, 12).


Meanwhile, several other studies show that TMG has no impact on exercise performance or strength. Still, it noted that in two studies, TMG supplements significantly increased muscle strength and power ( 9).
